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soul trial oral semaglutide cardiovascular outcomes results 2025 nejm An oral formulation of semaglutide lowered the risk major adverse cardiovascular events by 14% in four years, with no change in safety profile compared to placebo, according to the SOUL study. #ACC25

Marsoni M251S
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4.1 ★★★★★
Based on 2488 reviews
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Marie Phillips
Alexandria, US
★★★★★ 4
Durable Chew Toy That Actually Holds Up to Strong Jaws
Size: Large, Color: Bundle
This is a reliable option for a heavy chewer, especially for a large breed with a strong bite. The material feels tough and well-made, and it stands up well to consistent chewing without immediately breaking down like softer toys tend to do. It also gives a bit of dental benefit by helping reduce plaque and tartar buildup during play, which is a nice bonus since brushing isn’t always realistic. The textured surface keeps it interesting enough to hold attention for a while, and it doesn’t splinter or create a mess. Overall, it’s a solid, durable chew toy that works well for strong chewers who tend to destroy most standard toys quickly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 6, 2026
J
Verified Purchase
Justina Stone
Fort Morgan, US
★★★★★ 5
Ergonomic good, material so, so
Size: Large, Color: Wishbone
Nice ergonomic, but the plastic come off and dog chew it. I had rather have a stronger material adequate for bigger dogs.
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Reviewed in the United States on April 30, 2026
M
Verified Purchase
Myah Meyers
Carnegie, US
★★★★★ 3
Love it, nice for tough chewers, split in half during play
Size: X-Large, Color: Textured Ring, Size: X-Large, Color: Textured Ring
LOVE THIS PRODUCT, would’ve gotten 5 stars but i threw it for my dog and it split in half on contact with the floor. It had lasted us well over 5 months, it’s not his favorite toy but he’ll pick it sometimes, i wouldn’t say it’s unsafe in half just don’t give the smaller parts!
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Reviewed in the United States on December 18, 2025
J
Verified Purchase
Jh
San Leandro, US
★★★★★ 5
Dogs love them
Size: X-Large, Color: Textured Ring
Great for aggressive chewers . hold up well
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Reviewed in the United States on April 26, 2026
S
Verified Purchase
Sarah Hood
Belleville, US
★★★★★ 5
Great for power chewers
Size: Large, Color: Bundle
Nothing beats Nylabone!!! Our lab has destroyed everything else… even the extra durable black kongs. Finally a chew toy that is super durable and great size.
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Reviewed in the United States on June 12, 2026

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